Version 5.4
Homo sapiens Protein: FIGN
Summary
InnateDB Protein IDBP-73832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIGN
Protein Name fidgetin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333836
InnateDB Gene IDBG-73830 (FIGN)
Protein Structure
UniProt Annotation
Function ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. {ECO:0000269PubMed:22672901}.
Subcellular Localization Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:22672901}. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0007067 mitotic nuclear division
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00004
PF07724
PF13304
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5HY92
PhosphoSite PhosphoSite-Q5HY92
TrEMBL
UniProt Splice Variant
Entrez Gene 55137
UniGene Hs.593650
RefSeq NP_060556
HUGO HGNC:13285
OMIM 605295
CCDS CCDS2221
HPRD 07287
IMGT
EMBL AC093727 AK001267 AK025747 AK125324 BX649105
GenPept AAX81992 BAA91590 BAB15231 BAG54182 CAI45980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca