InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPK

Summary

InnateDB Protein

IDBP-73960.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPK

Protein Name

heterogeneous nuclear ribonucleoprotein K

Synonyms

CSBP; HNRPK; TUNP;

Species

Homo sapiens

Ensembl Protein

ENSP00000353552

InnateDB Gene

IDBG-73948 (HNRNPK)

Protein Structure

UniProt Annotation

Function

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269PubMed:16360036, ECO:0000269PubMed:20673990, ECO:0000269PubMed:22825850}.

Subcellular Localization

Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 279 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	279 [view]
Protein-Protein	273 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006396	RNA processing
GO:0007165	signal transduction
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0010988	regulation of low-density lipoprotein particle clearance
GO:0016032	viral process
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0002102	podosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030054	cell junction
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome