InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARCN1

Summary

InnateDB Protein

IDBP-73984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARCN1

Protein Name

archain 1

Synonyms

COPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000264028

InnateDB Gene

IDBG-73982 (ARCN1)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0008344	adult locomotory behavior
GO:0016192	vesicle-mediated transport
GO:0021691	cerebellar Purkinje cell layer maturation
GO:0043473	pigmentation
GO:0048193	Golgi vesicle transport
GO:0048205	COPI coating of Golgi vesicle
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030126	COPI vesicle coat
GO:0030131	clathrin adaptor complex
GO:0030137	COPI-coated vesicle
GO:0043231	intracellular membrane-bounded organelle