InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL9L

Summary

InnateDB Protein

IDBP-74065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL9L

Protein Name

B-cell CLL/lymphoma 9-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000335320

InnateDB Gene

IDBG-74063 (BCL9L)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17129358, ECO:0000269PubMed:17309600}.

Disease Associations

Tissue Specificity

Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor. {ECO:0000269PubMed:12964048, ECO:0000269PubMed:17129358, ECO:0000269PubMed:17309600}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0008013	beta-catenin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0022604	regulation of cell morphogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0035914	skeletal muscle cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway