InnateDB Protein
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IDBP-74104.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UPK2
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Protein Name
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uroplakin 2
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Synonyms
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UP2; UPII;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264031
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InnateDB Gene
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IDBG-74102 (UPK2)
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Protein Structure
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Function |
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in ureter. {ECO:0000269PubMed:9846985}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009952
Uroplakin II
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PFAM |
PF07353
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PRINTS |
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PIRSF |
PIRSF016439
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O00526
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PhosphoSite |
PhosphoSite-O00526
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TrEMBL |
Q9UEE8
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UniProt Splice Variant |
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Entrez Gene |
7379
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UniGene |
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RefSeq |
NP_006751
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HUGO |
HGNC:12579
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OMIM |
611558
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CCDS |
CCDS8404
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HPRD |
10295
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IMGT |
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EMBL |
AB009454
AB078607
AF000562
AY455312
BC113900
EF445028
Y13645
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GenPept |
AAB58416
AAI13901
AAR19396
ACA06070
BAA23884
BAB84089
CAA73996
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