InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RMI1

Summary

InnateDB Protein

IDBP-74114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RMI1

Protein Name

RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317039

InnateDB Gene

IDBG-74108 (RMI1)

Protein Structure

UniProt Annotation

Function

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269PubMed:15775963, ECO:0000269PubMed:16537486, ECO:0000269PubMed:16595695}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15775963}. Note=Forms foci in response to DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002021	response to dietary excess
GO:0002023	reduction of food intake in response to dietary excess
GO:0006260	DNA replication
GO:0009749	response to glucose
GO:0035264	multicellular organism growth
GO:0042593	glucose homeostasis