InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPTBN5

Summary

InnateDB Protein

IDBP-7418.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN5

Protein Name

spectrin, beta, non-erythrocytic 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317790

InnateDB Gene

IDBG-7416 (SPTBN5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton. Note=Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.

Disease Associations

Tissue Specificity

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0030507	spectrin binding
GO:0032029	myosin tail binding
GO:0034452	dynactin binding
GO:0043621	protein self-association
GO:0045505	dynein intermediate chain binding

Biological Process

GO:0007030	Golgi organization
GO:0007041	lysosomal transport
GO:0007411	axon guidance
GO:0030036	actin cytoskeleton organization
GO:0051260	protein homooligomerization
GO:0051693	actin filament capping

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008091	spectrin
GO:0016020	membrane
GO:0032391	photoreceptor connecting cilium
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0097381	photoreceptor disc membrane