InnateDB Protein
|
IDBP-741955.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Plscr2
|
Protein Name
|
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000136481
|
InnateDB Gene
|
IDBG-191135 (Plscr2)
|
Protein Structure
|
|
Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
|
Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in erythrocyte membranes, blood platelets, blood leukocytes, T- and B-lymphocytes, vascular endothelium, spleen, thymus, prostate, testis, uterus, intestine and colon.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0071222
|
cellular response to lipopolysaccharide
|
|
Cellular Component |
|
PDB ID |
MGI:1270860
|
InterPro |
IPR005552
Scramblase
|
PFAM |
PF03803
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9DCW2
|
PhosphoSite |
PhosphoSite-Q9DCW2
|
TrEMBL |
D3Z7J3
|
UniProt Splice Variant |
|
Entrez Gene |
18828
|
UniGene |
Mm.417517
|
RefSeq |
NP_032906
|
MGI ID |
|
MGI Symbol |
Plscr2
|
OMIM |
|
CCDS |
CCDS23405
|
HPRD |
|
IMGT |
|
EMBL |
AC111125
AF015790
AK002410
BC002012
BC011299
CH466560
|
GenPept |
AAC40053
AAH02012
AAH11299
BAB22079
EDL20918
|
|
|