Version 5.4
Mus musculus Protein: Cxcr5
Summary
InnateDB Protein IDBP-742101.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcr5
Protein Name
Synonyms Blr1; CXC-R5; CXCR-5; Gpcr6; MDR15;
Species Mus musculus
Ensembl Protein ENSMUSP00000137518
InnateDB Gene IDBG-157659 (Cxcr5)
Protein Structure
UniProt Annotation
Function Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Mainly in spleen, in resting B-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016494 C-X-C chemokine receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032467 positive regulation of cytokinesis
GO:0042113 B cell activation
GO:0048535 lymph node development
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:103567
InterPro IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001053 CXC chemokine receptor 5
IPR001277 CXC chemokine receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00241
PR00237
PR00564
PR00645
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q04683
PhosphoSite PhosphoSite-Q04683
TrEMBL
UniProt Splice Variant
Entrez Gene 12145
UniGene Mm.6246
RefSeq
MGI ID
MGI Symbol Cxcr5
OMIM
CCDS CCDS23115
HPRD
IMGT
EMBL AK155954 AK156087 AK157016 BC064059 CH466522 L20332 X71788
GenPept AAA16852 AAH64059 BAE33519 BAE33583 BAE33932 CAA50673 EDL25602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca