InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ryk

Summary

InnateDB Protein

IDBP-742250.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryk

Protein Name

Synonyms

AW536699; ERK-3; Vik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135858

InnateDB Gene

IDBG-194079 (Ryk)

Protein Structure

UniProt Annotation

Function

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269PubMed:15454084, ECO:0000269PubMed:16116452, ECO:0000269PubMed:16723543, ECO:0000269PubMed:19000841}.

Subcellular Localization

Membrane {ECO:0000269PubMed:19000841}; Single-pass type I membrane protein {ECO:0000269PubMed:19000841}. Nucleus {ECO:0000269PubMed:19000841}. Cytoplasm {ECO:0000269PubMed:19000841}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.

Disease Associations

Tissue Specificity

Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0016055	Wnt signaling pathway
GO:0022038	corpus callosum development
GO:0030182	neuron differentiation
GO:0031175	neuron projection development
GO:0043410	positive regulation of MAPK cascade
GO:0048705	skeletal system morphogenesis
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:101766

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003306 WIF domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF02019

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00469
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt