Version 5.4
Mus musculus Protein: Oaz2
Summary
InnateDB Protein IDBP-742370.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oaz2
Protein Name
Synonyms AZ-2; AZ2; Oaz2-ps; Sez15;
Species Mus musculus
Ensembl Protein ENSMUSP00000136914
InnateDB Gene IDBG-178329 (Oaz2)
Protein Structure
UniProt Annotation
Function Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). {ECO:0000269PubMed:16916800, ECO:0000269PubMed:18508777, ECO:0000269PubMed:19449338, ECO:0000269PubMed:24967154}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19725046}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008073 ornithine decarboxylase inhibitor activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:109492
InterPro IPR002993 Ornithine decarboxylase antizyme
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF02100
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08608
PhosphoSite PhosphoSite-O08608
TrEMBL
UniProt Splice Variant
Entrez Gene 18247
UniGene Mm.473237
RefSeq NP_035082
MGI ID
MGI Symbol Oaz2
OMIM
CCDS CCDS57683
HPRD
IMGT
EMBL AF057298 D78643
GenPept AAD03266 BAA19569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca