InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il18

Summary

InnateDB Protein

IDBP-742396.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il18

Protein Name

Synonyms

Igif; Il-18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137193

InnateDB Gene

IDBG-163502 (Il18)

Protein Structure

UniProt Annotation

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010628	positive regulation of gene expression
GO:0030101	natural killer cell activation
GO:0030155	regulation of cell adhesion
GO:0030431	sleep
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0042088	T-helper 1 type immune response
GO:0042095	interferon-gamma biosynthetic process
GO:0042104	positive regulation of activated T cell proliferation
GO:0042231	interleukin-13 biosynthetic process
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0051142	positive regulation of NK T cell proliferation
GO:0071407	cellular response to organic cyclic compound