InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc38a3

Summary

InnateDB Protein

IDBP-742554.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc38a3

Protein Name

Synonyms

0610012J02Rik; D9Ucla2; mNAT; Nat1; Slc38-3; Sn1; Snat3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137561

InnateDB Gene

IDBG-198073 (Slc38a3)

Protein Structure

UniProt Annotation

Function

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. {ECO:0000250UniProtKB:Q9JHZ9, ECO:0000269PubMed:10716701}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10716701}; Multi-pass membrane protein {ECO:0000269PubMed:10716701}.

Disease Associations

Tissue Specificity

Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis. {ECO:0000269PubMed:10716701}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005290	L-histidine transmembrane transporter activity
GO:0015182	L-asparagine transmembrane transporter activity
GO:0015186	L-glutamine transmembrane transporter activity
GO:0015293	symporter activity
GO:0015297	antiporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0006867	asparagine transport
GO:0006868	glutamine transport
GO:0015817	histidine transport
GO:0055085	transmembrane transport