InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H2AFX

Summary

InnateDB Protein

IDBP-74261.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFX

Protein Name

H2A histone family, member X

Synonyms

H2A.X; H2A/X; H2AX;

Species

Homo sapiens

Ensembl Protein

ENSP00000364310

InnateDB Gene

IDBG-74259 (H2AFX)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. {ECO:0000269PubMed:10959836, ECO:0000269PubMed:12419185, ECO:0000269PubMed:12607005, ECO:0000269PubMed:15201865}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 302 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	302 [view]
Protein-Protein	298 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042393	histone binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006334	nucleosome assembly
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0010212	response to ionizing radiation
GO:0045739	positive regulation of DNA repair

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000786	nucleosome
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0035861	site of double-strand break