Version 5.4
Mus musculus Protein: Tirap
Summary
InnateDB Protein IDBP-742671.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tirap
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000135462
InnateDB Gene IDBG-148134 (Tirap)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007257 activation of JUN kinase activity
GO:0009617 response to bacterium
GO:0030099 myeloid cell differentiation
GO:0032496 response to lipopolysaccharide
GO:0032738 positive regulation of interleukin-15 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0090073 positive regulation of protein homodimerization activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2152213
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
PFAM PF01582
PF13676
PRINTS
PIRSF PIRSF037750
SMART SM00255
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q542S6
UniProt Splice Variant
Entrez Gene 117149
UniGene Mm.455568
RefSeq NP_473437
MGI ID
MGI Symbol Tirap
OMIM
CCDS CCDS40575
HPRD
IMGT
EMBL AC140448 AK036431 AK080135 AK168494 CH466522
GenPept BAC29426 BAC37831 BAE40381 EDL25378 EDL25380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca