InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RY4

Summary

InnateDB Protein

IDBP-74284.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY4

Protein Name

pyrimidinergic receptor P2Y, G-protein coupled, 4

Synonyms

NRU; P2P; P2Y4; UNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000363643

InnateDB Gene

IDBG-74282 (P2RY4)

Protein Structure

UniProt Annotation

Function

Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005524	ATP binding
GO:0015065	uridine nucleotide receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045030	UTP-activated nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0030321	transepithelial chloride transport
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane