InnateDB Protein
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IDBP-74343.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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G6PC2
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Protein Name
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glucose-6-phosphatase, catalytic, 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364512
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InnateDB Gene
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IDBG-74341 (G6PC2)
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Protein Structure
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Function |
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:15044018}; Multi-pass membrane protein {ECO:0000269PubMed:15044018}.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level). {ECO:0000269PubMed:11297555}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
IPR016275
Glucose-6-phosphatase
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PFAM |
PF01569
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PRINTS |
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PIRSF |
PIRSF000905
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SMART |
SM00014
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NQR9
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PhosphoSite |
PhosphoSite-Q9NQR9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57818
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UniGene |
Hs.283963
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RefSeq |
NP_066999
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HUGO |
HGNC:28906
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OMIM |
608058
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CCDS |
CCDS2230
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HPRD |
16272
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IMGT |
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EMBL |
AC069137
AF283835
BC104778
BC113376
BQ777188
CH471058
CR627438
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GenPept |
AAF82810
AAI04779
AAI13377
CAH10524
EAX11291
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