InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: G6PC2

Summary

InnateDB Protein

IDBP-74345.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6PC2

Protein Name

glucose-6-phosphatase, catalytic, 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282075

InnateDB Gene

IDBG-74341 (G6PC2)

Protein Structure

UniProt Annotation

Function

May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15044018}; Multi-pass membrane protein {ECO:0000269PubMed:15044018}.

Disease Associations

Tissue Specificity

Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level). {ECO:0000269PubMed:11297555}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004346	glucose-6-phosphatase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006094	gluconeogenesis
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0016311	dephosphorylation
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport