InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGMS1

Summary

InnateDB Protein

IDBP-74413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGMS1

Protein Name

sphingomyelin synthase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354829

InnateDB Gene

IDBG-74409 (SGMS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0033188	sphingomyelin synthase activity
GO:0047493	ceramide cholinephosphotransferase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006686	sphingomyelin biosynthetic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0016310	phosphorylation
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071356	cellular response to tumor necrosis factor
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000138	Golgi trans cisterna
GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF01569
PF00536

PRINTS

PIRSF

SMART

SM00014
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite