InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCAM

Summary

InnateDB Protein

IDBP-74430.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCAM

Protein Name

melanoma cell adhesion molecule

Synonyms

CD146; MUC18;

Species

Homo sapiens

Ensembl Protein

ENSP00000264036

InnateDB Gene

IDBG-74428 (MCAM)

Protein Structure

UniProt Annotation

Function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269PubMed:11036077, ECO:0000269PubMed:8292890}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0003094	glomerular filtration
GO:0007155	cell adhesion
GO:0009653	anatomical structure morphogenesis
GO:0030335	positive regulation of cell migration
GO:0061042	vascular wound healing

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43121