InnateDB Protein
|
IDBP-74461.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
A1CF
|
Protein Name
|
APOBEC1 complementation factor
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000363109
|
InnateDB Gene
|
IDBG-74457 (A1CF)
|
Protein Structure
|
|
Function |
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269PubMed:10669759, ECO:0000269PubMed:10781591, ECO:0000269PubMed:12881431}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269PubMed:10669759}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000504
RNA recognition motif domain
IPR006535
HnRNP R/Q splicing factor
|
PFAM |
PF00076
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NQ94
|
PhosphoSite |
PhosphoSite-Q9NQ94
|
TrEMBL |
Q7Z2U9
|
UniProt Splice Variant |
|
Entrez Gene |
29974
|
UniGene |
Hs.282795
|
RefSeq |
NP_055391
|
HUGO |
HGNC:24086
|
OMIM |
|
CCDS |
CCDS7241
|
HPRD |
10627
|
IMGT |
|
EMBL |
AF209192
AF271789
AF271790
AJ272078
AJ272079
AK000324
AK291982
AL512366
AL589794
BC054873
BC130519
BC144196
CH471083
|
GenPept |
AAF34824
AAF76221
AAF76222
AAH54873
AAI30520
AAI44197
BAA91086
BAF84671
CAB94754
CAB94755
CAI14233
CAI14235
CAI14236
CAI15762
CAI15763
CAI15764
EAW54133
EAW54134
EAW54135
EAW54136
|
|
|