InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NARFL

Summary

InnateDB Protein

IDBP-744929.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NARFL

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000457058

InnateDB Gene

IDBG-8238 (NARFL)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269PubMed:16956324, ECO:0000269PubMed:18270200}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:16956324}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0016226	iron-sulfur cluster assembly
GO:0032364	oxygen homeostasis
GO:0044281	small molecule metabolic process