Version 5.4
Homo sapiens Protein: MEX3B
Summary
InnateDB Protein IDBP-744952.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEX3B
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000456938
InnateDB Gene IDBG-26170 (MEX3B)
Protein Structure
UniProt Annotation
Function RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms.
Subcellular Localization Nucleus {ECO:0000269PubMed:18779327}. Cytoplasm {ECO:0000269PubMed:18779327}. Cytoplasm, P-body {ECO:0000269PubMed:18779327}. Cytoplasmic granule {ECO:0000269PubMed:18779327}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
Disease Associations
Tissue Specificity Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level. {ECO:0000269PubMed:17267406}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZN04
PhosphoSite PhosphoSite-Q6ZN04
TrEMBL
UniProt Splice Variant
Entrez Gene 84206
UniGene Hs.104744
RefSeq
HUGO HGNC:25297
OMIM 611008
CCDS
HPRD 15256
IMGT
EMBL AB095929 AK131424 AL136778 AY950678 BC036211 BC111545
GenPept AAH36211 AAI11546 AAY34146 BAC23105 BAD18571 CAB66712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca