InnateDB Protein
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IDBP-744985.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NAA60
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000460763
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InnateDB Gene
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IDBG-12057 (NAA60)
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Protein Structure
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Function |
Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. {ECO:0000269PubMed:21750686, ECO:0000269PubMed:21981917}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:21981917}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004596
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peptide alpha-N-acetyltransferase activity
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GO:0010485
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H4 histone acetyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016181
Acyl-CoA N-acyltransferase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H7X0
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PhosphoSite |
PhosphoSite-AAH11267
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TrEMBL |
I3L4T5
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UniProt Splice Variant |
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Entrez Gene |
79903
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UniGene |
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RefSeq |
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HUGO |
HGNC:25875
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OMIM |
614246
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CCDS |
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HPRD |
07852
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IMGT |
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EMBL |
AC004224
AC025283
AK024216
AK092005
AK297219
AK298566
AK302361
AY358543
BC011267
CH471112
CR457324
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GenPept |
AAH11267
AAQ88907
BAB14853
BAG52462
BAG59702
BAG60760
BAG63686
CAG33605
EAW85358
EAW85359
EAW85360
EAW85361
EAW85362
EAW85363
EAW85364
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