Version 5.4
Homo sapiens Protein: TTI1
Summary
InnateDB Protein IDBP-74511.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTI1
Protein Name Tel2 interacting protein 1 homolog (S. pombe)
Synonyms KIAA0406; smg-10;
Species Homo sapiens
Ensembl Protein ENSP00000362546
InnateDB Gene IDBG-74507 (TTI1)
Protein Structure
UniProt Annotation
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269PubMed:20427287, ECO:0000269PubMed:20801936, ECO:0000269PubMed:20810650}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:23263282}.
Disease Associations
Tissue Specificity Widely expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0032006 regulation of TOR signaling
Cellular Component
GO:0005737 cytoplasm
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
IPR016441 Uncharacterised conserved protein UCP005250
PFAM
PRINTS
PIRSF PIRSF005250
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43156
PhosphoSite PhosphoSite-O43156
TrEMBL D6W4K3
UniProt Splice Variant
Entrez Gene 9675
UniGene Hs.655481
RefSeq XP_005260678
HUGO HGNC:29029
OMIM 614425
CCDS CCDS13300
HPRD 13799
IMGT
EMBL AB007866 AL109823 BC013121 BC013755 BR000854 CH471077
GenPept AAH13121 AAH13755 BAA23702 CAI19022 EAW76047 EAW76048 FAA00688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca