InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MXD4

Summary

InnateDB Protein

IDBP-7455.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MXD4

Protein Name

MAX dimerization protein 4

Synonyms

bHLHc12; MAD4; MST149; MSTP149;

Species

Homo sapiens

Ensembl Protein

ENSP00000337889

InnateDB Gene

IDBG-7451 (MXD4)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated