InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGM2

Summary

InnateDB Protein

IDBP-74571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGM2

Protein Name

transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

Synonyms

G-ALPHA-h; GNAH; HEL-S-45; TG2; TGC;

Species

Homo sapiens

Ensembl Protein

ENSP00000355330

InnateDB Gene

IDBG-74569 (TGM2)

Protein Structure

UniProt Annotation

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	82 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0018149	peptide cross-linking
GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277	apoptotic cell clearance
GO:0045785	positive regulation of cell adhesion
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051260	protein homooligomerization
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060662	salivary gland cavitation