Version 5.4
Homo sapiens Protein: CCNDBP1
Summary
InnateDB Protein IDBP-745761.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNDBP1
Protein Name
Synonyms DIP1; GCIP; HHM;
Species Homo sapiens
Ensembl Protein ENSP00000455419
InnateDB Gene IDBG-8246 (CCNDBP1)
Protein Structure
UniProt Annotation
Function May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. {ECO:0000269PubMed:10801854}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. {ECO:0000269PubMed:10801854, ECO:0000269PubMed:10854051, ECO:0000269PubMed:10915743, ECO:0000269PubMed:15887118, ECO:0000269PubMed:17131381}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95273
PhosphoSite PhosphoSite-O95273
TrEMBL
UniProt Splice Variant
Entrez Gene 23582
UniGene Hs.723766
RefSeq
HUGO HGNC:1587
OMIM 607089
CCDS
HPRD 06156
IMGT
EMBL AF082569 AF087852 AF113535 AF132034 AF246144 AK075146 AK075296 AK128849 AK290665 AK290707 BC009689 CH471125 CR450331
GenPept AAD11777 AAF14872 AAF67182 AAF77613 AAH09689 AAP97163 BAC11433 BAC11530 BAC87645 BAF83354 BAF83396 CAG29327 EAW92588 EAW92590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca