InnateDB Protein
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IDBP-74591.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GOLM1
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Protein Name
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golgi membrane protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000373363
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InnateDB Gene
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IDBG-74585 (GOLM1)
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Protein Structure
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Function |
Unknown. Cellular response protein to viral infection.
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Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes. {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12029628}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NBJ4
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PhosphoSite |
PhosphoSite-Q8NBJ4
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TrEMBL |
C9JYM4
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UniProt Splice Variant |
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Entrez Gene |
51280
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UniGene |
Hs.635951
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RefSeq |
NP_808800
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HUGO |
HGNC:15451
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OMIM |
606804
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CCDS |
CCDS35054
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HPRD |
08428
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IMGT |
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EMBL |
AF236056
AK027717
AK075542
AK075557
AL161447
AY358593
BC001740
CH471089
CR457201
EU794616
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GenPept |
AAF44663
AAH01740
AAQ88956
ACJ13670
BAC11685
BAG51371
BAG52167
CAG33482
EAW62705
EAW62706
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