Version 5.4
Homo sapiens Protein: GOLM1
Summary
InnateDB Protein IDBP-74593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GOLM1
Protein Name golgi membrane protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373364
InnateDB Gene IDBG-74585 (GOLM1)
Protein Structure
UniProt Annotation
Function Unknown. Cellular response protein to viral infection.
Subcellular Localization Golgi apparatus, cis-Golgi network membrane {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12191016}; Single-pass type II membrane protein {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12191016}. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes. {ECO:0000269PubMed:10831838, ECO:0000269PubMed:12029628}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006997 nucleus organization
GO:0019216 regulation of lipid metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBJ4
PhosphoSite PhosphoSite-Q8NBJ4
TrEMBL C9JYM4
UniProt Splice Variant
Entrez Gene 51280
UniGene Hs.635951
RefSeq NP_057632
HUGO HGNC:15451
OMIM 606804
CCDS CCDS35054
HPRD 08428
IMGT
EMBL AF236056 AK027717 AK075542 AK075557 AL161447 AY358593 BC001740 CH471089 CR457201 EU794616
GenPept AAF44663 AAH01740 AAQ88956 ACJ13670 BAC11685 BAG51371 BAG52167 CAG33482 EAW62705 EAW62706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca