InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU2F3

Summary

InnateDB Protein

IDBP-74609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2F3

Protein Name

POU class 2 homeobox 3

Synonyms

Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a;

Species

Homo sapiens

Ensembl Protein

ENSP00000260264

InnateDB Gene

IDBG-74607 (POU2F3)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Specifically expressed in epidermis and cultured keratinocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008544	epidermis development
GO:0030216	keratinocyte differentiation
GO:0042060	wound healing
GO:0043922	negative regulation by host of viral transcription
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000327 POU-specific
IPR000972 Octamer-binding transcription factor
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00029
PR00028

PIRSF

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt