Version 5.4
Homo sapiens Protein: NPTN
Summary
InnateDB Protein IDBP-746184.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPTN
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000457028
InnateDB Gene IDBG-21125 (NPTN)
Protein Structure
UniProt Annotation
Function Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Enriched at postsynaptic density. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level). {ECO:0000269PubMed:17196182, ECO:0000269Ref.1}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007156 homophilic cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010976 positive regulation of neuron projection development
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y639
PhosphoSite PhosphoSite-Q9Y639
TrEMBL Q9UFM8
UniProt Splice Variant
Entrez Gene 27020
UniGene Hs.704983
RefSeq NP_001154835
HUGO HGNC:17867
OMIM 612820
CCDS CCDS58380
HPRD 18033
IMGT
EMBL AB209812 AC022735 AF109126 AF109127 AK297184 AK314248 AL117411 BC105979 BC117462 BC143880 BC143881 CH471082
GenPept AAD43217 AAD43218 AAI05980 AAI17463 AAI43881 AAI43882 BAD93049 BAG36914 BAH12519 CAB55909 EAW77931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca