Version 5.4
Homo sapiens Protein: ATMIN
Summary
InnateDB Protein IDBP-747514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATMIN
Protein Name
Synonyms ASCIZ; ZNF822;
Species Homo sapiens
Ensembl Protein ENSP00000455497
InnateDB Gene IDBG-43349 (ATMIN)
Protein Structure
UniProt Annotation
Function Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269PubMed:15933716, ECO:0000269PubMed:17525732, ECO:0000269PubMed:22167198}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15933716, ECO:0000269PubMed:17525732}. Note=Nuclear, in discrete foci during G1 phase.
Disease Associations
Tissue Specificity Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. {ECO:0000269PubMed:15933716}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0045502 dynein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43313
PhosphoSite PhosphoSite-O43313
TrEMBL J3QRX7
UniProt Splice Variant
Entrez Gene 23300
UniGene Hs.648187
RefSeq
HUGO HGNC:29034
OMIM 614693
CCDS CCDS73917
HPRD 17188
IMGT
EMBL AB007891 AC092718 AK290943 BC002701 CR749457
GenPept AAH02701 BAA24861 BAF83632 CAH18291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca