InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFB1I1

Summary

InnateDB Protein

IDBP-747935.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFB1I1

Protein Name

Synonyms

ARA55; HIC-5; HIC5; TSC-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000457586

InnateDB Gene

IDBG-28530 (TGFB1I1)

Protein Structure

UniProt Annotation

Function

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269PubMed:10075738, ECO:0000269PubMed:11463817, ECO:0000269PubMed:11856738, ECO:0000269PubMed:12177201, ECO:0000269PubMed:12445807, ECO:0000269PubMed:12700349, ECO:0000269PubMed:15211577, ECO:0000269PubMed:15561701, ECO:0000269PubMed:16141357, ECO:0000269PubMed:16624805, ECO:0000269PubMed:16803896, ECO:0000269PubMed:16849583, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:9032249}.

Subcellular Localization

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.

Disease Associations

Tissue Specificity

Expressed in platelets, smooth muscle and prostate stromal cells (at protein level). {ECO:0000269PubMed:10075738, ECO:0000269PubMed:10708479, ECO:0000269PubMed:11311131, ECO:0000269PubMed:12642630, ECO:0000269PubMed:12772188, ECO:0000269PubMed:16849583, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:9664039}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0048495	Roundabout binding
GO:0050681	androgen receptor binding
GO:0070411	I-SMAD binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0007155	cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated