InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A6

Summary

InnateDB Protein

IDBP-748084.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A6

Protein Name

Synonyms

LAT-2; LAT3; y+LAT-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000455064

InnateDB Gene

IDBG-38270 (SLC7A6)

Protein Structure

UniProt Annotation

Function

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. {ECO:0000269PubMed:10903140, ECO:0000269PubMed:11311135, ECO:0000269PubMed:14603368, ECO:0000269PubMed:15280038, ECO:0000269PubMed:16785209, ECO:0000269PubMed:17197568, ECO:0000269PubMed:17329401, ECO:0000269PubMed:9829974}.

Subcellular Localization

Basolateral cell membrane {ECO:0000269PubMed:15756301, ECO:0000269PubMed:16785209}; Multi- pass membrane protein {ECO:0000269PubMed:15756301, ECO:0000269PubMed:16785209}.

Disease Associations

Tissue Specificity

Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines. {ECO:0000269PubMed:11078698, ECO:0000269PubMed:11742806, ECO:0000269PubMed:14603368, ECO:0000269PubMed:15280038, ECO:0000269PubMed:17197568, ECO:0000269PubMed:17329401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015297	antiporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006461	protein complex assembly
GO:0006520	cellular amino acid metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0007596	blood coagulation
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane