Version 5.4
Homo sapiens Protein: ACTR5
Summary
InnateDB Protein IDBP-74895.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTR5
Protein Name ARP5 actin-related protein 5 homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000243903
InnateDB Gene IDBG-74893 (ACTR5)
Protein Structure
UniProt Annotation
Function Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269PubMed:19014934, ECO:0000269PubMed:20855601}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling. Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0070914 UV-damage excision repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031011 Ino80 complex
Protein Structure and Domains
PDB ID
InterPro IPR004000 Actin-related protein
PFAM PF00022
PRINTS PR00190
PIRSF
SMART SM00268
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H9F9
PhosphoSite PhosphoSite-Q9H9F9
TrEMBL
UniProt Splice Variant
Entrez Gene 79913
UniGene Hs.371585
RefSeq NP_079131
HUGO HGNC:14671
OMIM
CCDS CCDS13308
HPRD 08575
IMGT
EMBL AK022847 AL133519 AY211911 BC001324 BC006162 BC038402
GenPept AAH01324 AAH06162 AAH38402 AAO65164 BAB14270 CAD37358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca