Version 5.4
Homo sapiens Protein: DCAF17
Summary
InnateDB Protein IDBP-74900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF17
Protein Name DDB1 and CUL4 associated factor 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364404
InnateDB Gene IDBG-74898 (DCAF17)
Protein Structure
UniProt Annotation
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269PubMed:16949367}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000269PubMed:19026396}. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Disease Associations Woodhouse-Sakati syndrome (WoSaS) [MIM:241080]: Rare autosomal recessive disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. {ECO:0000269PubMed:19026396}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:19026396}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005730 nucleolus
GO:0016021 integral component of membrane
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5H9S7
PhosphoSite PhosphoSite-Q5H9S7
TrEMBL
UniProt Splice Variant
Entrez Gene 80067
UniGene Hs.659439
RefSeq NP_079276
HUGO HGNC:25784
OMIM 612515
CCDS CCDS2243
HPRD 08579
IMGT
EMBL AC007969 AK023158 BC120957 BC140843 CH471058 CR933646
GenPept AAI20958 AAI40844 AAY14729 BAB14436 CAI45947 EAX11213

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca