Version 5.4
Homo sapiens Protein: CISD1
Summary
InnateDB Protein IDBP-74908.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CISD1
Protein Name CDGSH iron sulfur domain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363041
InnateDB Gene IDBG-74906 (CISD1)
Protein Structure
UniProt Annotation
Function Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. {ECO:0000250, ECO:0000269PubMed:17584744, ECO:0000269PubMed:17766440}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:17376863, ECO:0000269PubMed:17766439, ECO:0000269PubMed:17905743, ECO:0000269PubMed:18047834}; Single- pass type III membrane protein {ECO:0000269PubMed:17376863, ECO:0000269PubMed:17766439, ECO:0000269PubMed:17905743, ECO:0000269PubMed:18047834}.
Disease Associations
Tissue Specificity Expression is reduced in cells derived from cystic fibrosis patients. {ECO:0000269PubMed:18047834}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0043457 regulation of cellular respiration
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006622 Iron sulphur-containing domain, CDGSH-type, subfamily
IPR018967 Iron sulphur-containing domain, CDGSH-type
IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
PFAM PF09360
PF10660
PRINTS
PIRSF
SMART SM00704
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZ45
PhosphoSite PhosphoSite-Q9NZ45
TrEMBL A0A024QZN7
UniProt Splice Variant
Entrez Gene 55847
UniGene Hs.738144
RefSeq NP_060934
HUGO HGNC:30880
OMIM 611932
CCDS CCDS7251
HPRD 12587
IMGT
EMBL AF220049 AK312017 AY960578 BC005962 BC007043 BC008474 BC059168 CH471083
GenPept AAF67642 AAH05962 AAH07043 AAH08474 AAH59168 AAY32336 BAG34955 EAW54163 EAW54164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca