InnateDB Protein
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IDBP-74930.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CYBRD1
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Protein Name
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cytochrome b reductase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319141
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InnateDB Gene
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IDBG-74928 (CYBRD1)
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Protein Structure
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Function |
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. {ECO:0000269PubMed:16521311, ECO:0000269PubMed:16521312, ECO:0000269PubMed:17068337, ECO:0000269PubMed:19673882}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:12949720}; Multi-pass membrane protein {ECO:0000269PubMed:12949720}.
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Disease Associations |
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Tissue Specificity |
Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. {ECO:0000269PubMed:16510471, ECO:0000269PubMed:17068337}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004877
Cytochrome b561, eukaryote
IPR006593
Cytochrome b561/ferric reductase transmembrane
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PFAM |
PF03188
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PRINTS |
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PIRSF |
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SMART |
SM00665
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TIGRFAMs |
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Modification |
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SwissProt |
Q53TN4
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PhosphoSite |
PhosphoSite-Q53TN4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79901
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UniGene |
Hs.741213
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RefSeq |
NP_079119
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HUGO |
HGNC:20797
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OMIM |
605745
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CCDS |
CCDS2244
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HPRD |
05764
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IMGT |
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EMBL |
AC007969
AJ715523
AJ715524
AK027115
AK128495
AK291731
AK301485
AK316588
AL136693
BC065290
CH471058
DQ496101
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GenPept |
AAH65290
AAY14730
ABF47090
BAB15661
BAC87466
BAF84420
BAG38176
BAG62999
CAB66628
CAG29366
CAG29367
EAX11210
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