Version 5.4
Homo sapiens Protein: CYBRD1
Summary
InnateDB Protein IDBP-74932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYBRD1
Protein Name cytochrome b reductase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364401
InnateDB Gene IDBG-74928 (CYBRD1)
Protein Structure
UniProt Annotation
Function Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. {ECO:0000269PubMed:16521311, ECO:0000269PubMed:16521312, ECO:0000269PubMed:17068337, ECO:0000269PubMed:19673882}.
Subcellular Localization Membrane {ECO:0000269PubMed:12949720}; Multi-pass membrane protein {ECO:0000269PubMed:12949720}.
Disease Associations
Tissue Specificity Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium. {ECO:0000269PubMed:16510471, ECO:0000269PubMed:17068337}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000293 ferric-chelate reductase activity
GO:0016722 oxidoreductase activity, oxidizing metal ions
GO:0046872 metal ion binding
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53TN4
PhosphoSite PhosphoSite-Q53TN4
TrEMBL
UniProt Splice Variant
Entrez Gene 79901
UniGene Hs.741213
RefSeq NP_001120855
HUGO HGNC:20797
OMIM 605745
CCDS CCDS46449
HPRD 05764
IMGT
EMBL AC007969 AJ715523 AJ715524 AK027115 AK128495 AK291731 AK301485 AK316588 AL136693 BC065290 CH471058 DQ496101
GenPept AAH65290 AAY14730 ABF47090 BAB15661 BAC87466 BAF84420 BAG38176 BAG62999 CAB66628 CAG29366 CAG29367 EAX11210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca