Version 5.4
Homo sapiens Protein: CNEP1R1
Summary
InnateDB Protein IDBP-749828.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNEP1R1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000456294
InnateDB Gene IDBG-30331 (CNEP1R1)
Protein Structure
UniProt Annotation
Function Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. {ECO:0000269PubMed:22134922}.
Subcellular Localization Nucleus membrane {ECO:0000269PubMed:22134922}; Multi-pass membrane protein {ECO:0000269PubMed:22134922}. Cytoplasm {ECO:0000269PubMed:22134922}. Note=Filamentous pattern in the cytoplasm.
Disease Associations
Tissue Specificity Muscle specific with lower expression in other metabolic tissues. {ECO:0000269PubMed:22134922}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006629 lipid metabolic process
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0034504 protein localization to nucleus
GO:0035307 positive regulation of protein dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0071595 Nem1-Spo7 phosphatase complex
Protein Structure and Domains
PDB ID
InterPro IPR019168 Nuclear envelope phosphatase-regulatory subunit 1
PFAM PF09771
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N9A8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 255919
UniGene Hs.741035
RefSeq
HUGO HGNC:26759
OMIM
CCDS
HPRD 08784
IMGT
EMBL AC007610 AK095420 BC022550 BC036683 CR933600
GenPept AAH22550 AAH36683 BAC04545 CAI45924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca