InnateDB Protein
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IDBP-749885.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZNF174
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Protein Name
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Synonyms
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ZSCAN8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000461502
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InnateDB Gene
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IDBG-11980 (ZNF174)
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Protein Structure
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Function |
Transcriptional repressor. {ECO:0000269PubMed:7673192}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0042803
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protein homodimerization activity
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR003309
Transcription regulator SCAN
IPR008916
Retrovirus capsid, C-terminal
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PFAM |
PF02023
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PRINTS |
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PIRSF |
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SMART |
SM00431
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TIGRFAMs |
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Modification |
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SwissProt |
Q15697
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PhosphoSite |
PhosphoSite-Q15697
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7727
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UniGene |
Hs.155204
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RefSeq |
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HUGO |
HGNC:12963
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OMIM |
603900
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CCDS |
CCDS32380
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HPRD |
04876
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IMGT |
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EMBL |
BC000876
BC001161
BT006923
U31248
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GenPept |
AAB04897
AAH00876
AAH01161
AAP35569
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