InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAT1

Summary

InnateDB Protein

IDBP-75012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAT1

Protein Name

histone acetyltransferase 1

Synonyms

KAT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000264108

InnateDB Gene

IDBG-75010 (HAT1)

Protein Structure

UniProt Annotation

Function

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269PubMed:11585814, ECO:0000269PubMed:20953179, ECO:0000269PubMed:9427644}.

Subcellular Localization

Isoform A: Nucleus matrix.Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0006323	DNA packaging
GO:0006325	chromatin organization
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006348	chromatin silencing at telomere
GO:0006475	internal protein amino acid acetylation
GO:0007584	response to nutrient
GO:0016568	chromatin modification
GO:0016573	histone acetylation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR016181 Acyl-CoA N-acyltransferase
IPR017380 Histone acetyltransferase type B, catalytic subunit
IPR019467 Histone acetyl transferase HAT1 N-terminal

PFAM

PF10394

PRINTS

PIRSF

PIRSF038084

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14929