InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF174

Summary

InnateDB Protein

IDBP-750748.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF174

Protein Name

Synonyms

ZSCAN8;

Species

Homo sapiens

Ensembl Protein

ENSP00000460397

InnateDB Gene

IDBG-11980 (ZNF174)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. {ECO:0000269PubMed:7673192}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-templated