InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLX2

Summary

InnateDB Protein

IDBP-75081.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLX2

Protein Name

distal-less homeobox 2

Synonyms

TES-1; TES1;

Species

Homo sapiens

Ensembl Protein

ENSP00000234198

InnateDB Gene

IDBG-75079 (DLX2)

Protein Structure

UniProt Annotation

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021772	olfactory bulb development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045746	negative regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048755	branching morphogenesis of a nerve
GO:0051216	cartilage development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
IPR022135 Distal-less-like homeobox protein, N-terminal domain

PFAM

PF00046
PF12413

PRINTS

PR00031
PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt