InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK20

Summary

InnateDB Protein

IDBP-75091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK20

Protein Name

cyclin-dependent kinase 20

Synonyms

CCRK; CDCH; P42; PNQALRE;

Species

Homo sapiens

Ensembl Protein

ENSP00000322343

InnateDB Gene

IDBG-75085 (CDK20)

Protein Structure

UniProt Annotation

Function

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. {ECO:0000250, ECO:0000269PubMed:14597612}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14597612}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0051301	cell division
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt