InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G4D

Summary

InnateDB Protein

IDBP-7512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G4D

Protein Name

phospholipase A2, group IVD (cytosolic)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000290472

InnateDB Gene

IDBG-7510 (PLA2G4D)

Protein Structure

UniProt Annotation

Function

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269PubMed:14709560}.

Subcellular Localization

Cytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. {ECO:0000269PubMed:14709560}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004623	phospholipase A2 activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process