InnateDB Protein
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IDBP-751408.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NDRG4
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000458113
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InnateDB Gene
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IDBG-34297 (NDRG4)
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Protein Structure
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Function |
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000250, ECO:0000269PubMed:12755708}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:12755708, ECO:0000269PubMed:19592488}.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. {ECO:0000269PubMed:11352569, ECO:0000269PubMed:12755708, ECO:0000269PubMed:19592488}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004142
NDRG
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF03096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULP0
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PhosphoSite |
PhosphoSite-Q9ULP0
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TrEMBL |
H3BUK1
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UniProt Splice Variant |
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Entrez Gene |
65009
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UniGene |
Hs.729314
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RefSeq |
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HUGO |
HGNC:14466
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OMIM |
614463
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CCDS |
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HPRD |
14817
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IMGT |
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EMBL |
AB021172
AB033006
AB044944
AB044945
AB044946
AB044947
AC009118
AF308608
AK055038
AK126574
AK131248
AK296415
AK299949
AK316089
AL136584
BC011795
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GenPept |
AAH11795
AAL08806
BAA86494
BAB20068
BAB20069
BAB20070
BAB20071
BAB20072
BAB20073
BAB20288
BAC86600
BAD18428
BAG51454
BAG59078
BAG61777
BAH14460
CAB66519
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