InnateDB Protein
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IDBP-751452.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATMIN
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Protein Name
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Synonyms
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ASCIZ; ZNF822;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000463478
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InnateDB Gene
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IDBG-43349 (ATMIN)
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Protein Structure
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Function |
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269PubMed:15933716, ECO:0000269PubMed:17525732, ECO:0000269PubMed:22167198}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15933716, ECO:0000269PubMed:17525732}. Note=Nuclear, in discrete foci during G1 phase.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. {ECO:0000269PubMed:15933716}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43313
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PhosphoSite |
PhosphoSite-O43313
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TrEMBL |
J3QRX7
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UniProt Splice Variant |
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Entrez Gene |
23300
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UniGene |
Hs.648187
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RefSeq |
NP_001287657
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HUGO |
HGNC:29034
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OMIM |
614693
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CCDS |
CCDS73917
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HPRD |
17188
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IMGT |
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EMBL |
AB007891
AC092718
AK290943
BC002701
CR749457
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GenPept |
AAH02701
BAA24861
BAF83632
CAH18291
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