Version 5.4
Homo sapiens Protein: CCDC6
Summary
InnateDB Protein IDBP-75159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC6
Protein Name coiled-coil domain containing 6
Synonyms D10S170; H4; PTC; TPC; TST1;
Species Homo sapiens
Ensembl Protein ENSP00000263102
InnateDB Gene IDBG-75157 (CCDC6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be a cytoskeletal protein.
Disease Associations Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
Tissue Specificity Ubiquitously expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 29 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR019152 Protein of unknown function DUF2046
PFAM PF09755
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16204
PhosphoSite PhosphoSite-Q16204
TrEMBL
UniProt Splice Variant
Entrez Gene 8030
UniGene Hs.591360
RefSeq NP_005427
HUGO HGNC:18782
OMIM 601985
CCDS CCDS7257
HPRD 09064
IMGT
EMBL AC023904 AC060231 AK292593 BC036757 BC064391 CH471083 M31213 S72869
GenPept AAA36524 AAC60637 AAH36757 AAH64391 BAF85282 EAW54196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca